BIOLOGICAL SCAFFOLDS
HYALOFAST®
One step regeneration for cartilage repair
BIOLOGICAL SCAFFOLDS
HYALOFAST®
One step regeneration for cartilage repair
BIOLOGICAL SCAFFOLDS
HYALOFAST®
What is HYALOFAST®?
HYALOFAST® is a 3D, biodegradable non-woven scaffold composed of HYAFF® (esterified hyaluronic acid) fibres.
How Does HYALOFAST® Work?
It is used in combination with mesenchymal stem cells (MSCs) to support hyaline-like cartilage regeneration in the knee, the ankle and the hip.
Hyalofast: A Single-Stage Hyaluronic Acid Matrix for Cartilage Repair
Hyalofast® is a biodegradable, non-woven scaffold composed of HYAFF® (benzyl ester of hyaluronic acid) intended as support for the entrapment of mesenchymal stem cells (MSC) for the repair of chondral and osteochondral lesions. It acts as a support for bone marrow aspirate (BMA), bone marrow aspirate concentrate (BMAC), or as a chondroprotective coverage which favors in situ residence of mesenchymal stem cells after their mobilization following bone marrow stimulation procedures.
Hyalofast fibers favor cell adhesion, allowing MSC arrangement inside the three-dimensional matrix. Once implanted, it fills the defect and temporarily substitutes the chondral and osteochondral tissue in the lesion until it is absorbed and replaced by the cartilage tissue. As the HYAFF fibers degrade, the polymer releases the parent molecule enriching the implantation site with hyaluronic acid, a naturally occurring extracellular matrix molecule and a major component of human cartilage.
The unique handling properties of Hyalofast make it quickly and easily implantable via arthroscopy or mini-arthrotomy. The soft texture allows it to conform easily to the lesion anatomy. It readily adheres to the site of application without requiring additional fixation in most cases. The scaffold can be applied in any orientation or stacked due to its uniform single-layer 3D structure.
Hyalofast has been clinically demonstrated to be safe and effective in medium-to-long-term follow-up of 8 years in the repair of ankle, knee or hip chondral and osteochondral lesions, permitting the filling of the lesion with a high volume of new hyaline-like cartilage tissue, and smooth integration with the surrounding cartilage. Patients reported reduction in pain and good functional improvement of the affected injured joint, thus enabling return to their daily/non-impact sport activities with substantial pain relief and high satisfaction.
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Cartilage Repair
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Cartilage Repair
Cartilage repair focuses on joint preservation techniques. It addresses the damaged surface of the knee joint, providing pain relief and improving its natural cushioning and smoothness.
HYAFF® Technology
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HYAFF® Technology
HYAFF® is the benzyl ester of Hyaluronic Acid (HA) - the main component of synovial fluid and acts as a lubricating and a shock absorbing molecule inside the joint.
HYAFF® fibres in a non-woven configuration have been proven to be an optimal scaffold for mesenchymal stem cells to regenerate into strong, healthy cartilage tissue.
Mesenchymal Stem Cells (MSCs)
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Mesenchymal Stem Cells (MSCs)
Think of MSCs as your body's versatile repair crew. They are special cells that can multiply on their own and turn into the building blocks for key parts of your skeleton, like bone or cartilage, when placed in the right setting.
HYALOFAST® anchors them at the damaged site, where they transform into cartilage-producing cells to restore hyaline-like cartilage.
Hear from our doctors and patients
The only 100% hyaluronic acid-based scaffold
VERSATILE
- Arthroscopic or mini open
- Effective for chondral and osteo-chondral defects
- Can be used together with NanoFx® or Marrow Cellution
EASY TO USE
- Good adherence
- Conformable, foldable, stackable
- Apply either side up
- 2 sizes available (2x2cm and 5x5cm), cut to shape
SAFE
- HYAFF® derivatives used for more than 20 years with excellent results
- 100% pure HA from bacteria, non-animal-based product
- Resorbed following the natural pathway of endogenous hyaluronic acid
HYALOFAST® is available in all restructured and private hospitals.
Speak with your orthopaedic surgeon to see if it’s the right option for you.
FAQs
HYALOFAST® is made of HYAFF®, the benzyl ester of Hyaluronic Acid (HA). It is the main component of synovial fluid and acts as a lubricating and a shock absorbing molecule inside the joint.
Patients with cartilage defects in the knee, hip or ankle may benefit. Speak with your orthopaedic surgeon to assess if it’s the right option for you.
Yes, when performed by qualified orthopedic surgeons, HYALOFAST® implantation is safe.
Patients may return home after a day or two and resume light activities within weeks. Individual healing times vary; your orthopaedic surgeon will provide a personalized recovery plan.
What is the difference between a knee procedure using HYALOFAST® and a Total Knee Replacement (TKR)?
A HYALOFAST® procedure and a TKR both aim to help with knee pain, but they encompass very different approaches. A HYALOFAST® procedure is knee-preserving while a TKR is knee-sacrificing.
A HYALOFAST® procedure keeps your natural joint intact. It is like a patch-up job to help your body’s own repair crew (mesenchymal stem cells) rebuild natural cartilage in the damaged area. It’s a minimally invasive procedure, often done through keyhole surgery. It helps you get back to light activities like walking within weeks.
A TKR removes the whole knee joint (cartilage and bone) and replaces it with a metal and plastic implant. It is like replacing the entire engine of a car. Recovery takes longer, often 6-12 months. It’s a bigger surgery with more restrictions, like avoiding high-impact activities long-term.
Speak with your orthopaedic surgeon to assess if it’s the right option for you.
Yes, HYALOFAST® works great with NanoFx®, a technique that makes tiny holes in the underlying bone to release mesenchymal stem cells. Think of NanoFx® as opening the door for the repair crew, while HYALOFAST® gives them a base to build strong cartilage. Together, they create a smoother, longer-lasting repair for your joints.
HYALOFAST® is designed to help you get back to everyday life, like walking to the wet market or playing your favourite sports. It helps regrow natural cartilage that mimics your natural joint, so you can move with less pain. Your orthopaedic surgeon will guide you on what’s safe based on your injury.
No, HYALOFAST® can help a wide range of people, from young athletes with sports injuries to older adults with cartilage wear and tear. Your orthopaedic surgeon can check if it’s right for you, no matter your age or activity level.
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