CRITICAL CARE
Octaplex
CRITICAL CARE
Octaplex
Octaplex® is a prothrombin complex concentrate (PCC) containing therapeutic and balanced levels of Factors II, VII, IX and X, as well as inhibitory proteins C and S. Octaplex® has been shown to provide rapid INR reversal within 10 minutes1, with a small volume (500 IU in 20 mL per vial) and short infusion time2.
Octaplex: Human Prothrombin Complex Concentrate
Fast and Accurate Control
Octaplex® is indicated for the treatment of bleeding and perioperative prophylaxis of bleeding in acquired deficiency of the prothrombin complex coagulation factors, such as deficiency caused by treatment with vitamin K antagonists, or overdose of vitamin K antagonists, when rapid correction of the deficiency is required. It can also be used in the treatment of bleeding and perioperative prophylaxis in congenital deficiency of the vitamin K dependent coagulation factors II and X when purified specific coagulation factor product is not available3.
References
Lubetsky A et al. Efficacy and safety of a prothrombin complex concentrate (Octaplex®) for rapid reversal of oral anticoagulation. Thromb Res 2004; 113(6): 371 – 378
Sarode R. Four-factor prothrombin complex concentrate versus plasma for urgent vitamin K antagonist reversal: New evidence. Clin Lab Med 2014; 34 (3): 613 – 621
- Summary of Product Characteristics of Octaplex®
Key Features & Benefits
Haemostatic balance of prothrombin complex coagulation factors
Therapeutic concentrations of protein C and protein S
Low thrombogenic profile Rapid INR reversal within 10 minutes Small volume and short infusion time
References
- Product information Octaplex
- Internal data
- Josic D, et al. Manufacturing of a Prothrombin Complex Concentrate Aiming at Low Thrombogenicity. Thromb Res 2000; 100: 433-441
- Lubetsky A et al. Effi cacy and safety of a prothrombin complex concentrate (Octaplex®) for rapid reversal of oral anticoagulation. Thromb Res 2004; 113(6):371-378
- Varga C et al. The effectiveness and safety of fixed low-dose prothrombin complex concentrates in patients requiring urgent reversal of warfarin. Transfusion 2013; 53:1451-1458
- Desmesttre T et al. Emergency reversal of anticoagulation: The real use of prothrombin complex concentrates – A prospective multicenter two year French study from 2006 to 2008. Thromb Res 2012; 130 (3): e178–e183
- Sarode R. Four-factor prothrombin complex concentrate versus plasma for urgent vitamin K antagonist reversal: New evidence. Clin Lab Med 2014; 34 (3): 613–621
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